Zu keiner Zeit hat Potsdam auf die europäische Kultur einen größeren Einfluss ausgeübt als im 18. Jahrhundert, als Friedrich der Große, der Philosophenkönig, den Absolutismus und die Aufklärung miteinander in Einklang zu bringen versuchte. Seit dem Beginn des 18. Jahrhunderts setzte der Aufstieg des Bürgertums in Verbindung mit den neuen Ideen der Aufklärung das höfische Monopol immer stärker unter Druck. Friedrich der Große nahm die Herausforderung an und wollte als König und Bürger der Leserepublik, als Herrscher und Intellektueller, Macht und (...) Geist zueinander führen. Der Hof in Potsdam, die Residenz am Rande der Metropole, wurde zum Ort dieses komplexen und spannungsreichen Rollenspiels, in dem die alte Welt der ererbten Herren und die neue Welt der kritischen Bürger ihre Grenzen auslotete. Das geschah unter den Augen Europas. Denn Friedrich der Große hatte dem Experiment Potsdam von Anfang an einen europäischen Rahmen gegeben. In Potsdam traf sich und auf Potsdam blickte die aufgeklärte Intelligenz aus ganz Europa. Die deutschen Aufklärer betrachteten das Rollenspiel vor den Toren Berlins dagegen skeptischer, weil sie der kulturellen Konstellation misstrauten und der europäische Hof quer lag zum großen Ziel einer deutschen Nationalkultur, für die der Philosoph von Sans-Souci so wenig Sinn zeigte. (shrink)

Human behavior depends on the ability to effectively introspect about our performance. For simple perceptual decisions, this introspective or metacognitive ability varies substantially across individuals and is correlated with the structure of focal areas in prefrontal cortex. This raises the possibility that the ability to introspect about different perceptual decisions might be mediated by a common cognitive process. To test this hypothesis, we examined whether inter-individual differences in metacognitive ability were correlated across two different perceptual tasks where individuals made judgments (...) about different and unrelated visual stimulus properties. We found that inter-individual differences were strongly correlated between the two tasks for metacognitive ability but not objective performance. Such stability of an individual’s metacognitive ability across different perceptual tasks indicates a general mechanism supporting metacognition independent of the specific task. (shrink)

New class of therapies, including bipolar therapies (BPT) and paradoxical unipolar therapies (PUT) were firstly proposed in relation to a clinical insight and to some results of biological investigations, then they gave rise to mathematical modeling which brought a justification of these therapies, at least from a theoretical point of view. After recalling the mathematical model for the regulation of agonistic antagonistic couples, and reporting the fundamental types of control simulation by means of it, we point out the validity of (...) therapeutical applications inferred from this model. These therapy modalities, including BPT and PUT, now concern the following diseases: astrocytomas, epilepsia and trials on multiple sclerosis. Even if such attempts are in their early stage, noticeably for the last case where biological changes have mainly been studied, it seems that a large span of treatments is open to BPT and PUT. Improvement of these techniques in the future depends, in our opinion, on a parallel working on the dynamics of the mathematical model and the dynamics, perceived by clinical insight and confirmed by biological investigations, of the body reactions to such strategies. Justification of BPT and PUT was given, by resorting to the notion of pathological homeostasis which, too often, intervenes in order to nullify the effects of unilateral (not paradoxical) therapies. This research has elicited some therapies which use two agents with antagonistic effects or only an agent with effects similar to the agent already in excess in the body - in both cases at nearly physiological doses. (shrink)

Introspection, or metacognition, is the capacity to reflect on our own thoughts and behaviours. Here, we investigated how one specific metacognitive ability develops in adolescence, a period of life associated with the emergence of self-concept and enhanced self-awareness. We employed a task that dissociates objective performance on a visual task from metacognitive ability in a group of 56 participants aged between 11 and 41 years. Metacognitive ability improved significantly with age during adolescence, was highest in late adolescence and plateaued going (...) into adulthood. Our results suggest that awareness of one’s own perceptual decisions shows a prolonged developmental trajectory during adolescence. (shrink)

The active debate about the return of incidental or secondary findings in research has primarily focused on return to research participants, or in some cases, family members. Particular attention has been paid to return of genomic findings. Yet, research may generate other types of findings that warrant consideration for return, including findings related to the pathology of donated biospecimens. In the case of deceased biospecimen donors who are also organ and/or tissue transplant donors, pathology incidental findings may be relevant not (...) to family members, but to potential organ or tissue transplant recipients. This paper will describe the ethical implications of pathology incidental findings in the Genotype-Tissue Expression project, the process for developing a consensus approach as to if/when such findings should be returned, possible implications for other research projects collecting postmortem tissues and how the scenario encountered in GTEx fits into the larger return of results/incidental findings debate. (shrink)

Expression of sexually dimorphic behaviors critical for reproduction depends on the organizational actions of steroid hormones on the developing brain. We offer the new hypothesis that transcriptional activities in brain regions executing these sexually dimorphic behaviors are modulated by estrogen‐induced modifications of histone proteins. Specifically, in preoptic nerve cells responsible for facilitating male sexual behavior in rodents, gene expression is fostered by increased histone acetylation and reduced methylation (Me), and, that the opposite set of histone modifications will be found in (...) females. Conversely, in ventromedial hypothalamic neurons that are responsible for coordinating female sexual behavior, transcriptional activities in genetic females are fostered by increased histone acetylation and reduced Me, and, further, that the opposite set of histone modifications will be found in males. Thus, these epigenetic events will guarantee that effects of sex hormone exposure during the neonatal critical period will be translated into lasting sex differences in adult reproductive behaviors. (shrink)

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The National Institutes of Health Clinical Center's Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the (...) range of consent strategies, and gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. This article describes areas of agreement and areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and tim.. (shrink)

A summary of the career of a Russian engineer who practiced a century ago in western Europe, as well as in Russia, provides an example of how ethical standards can influence practice across national boundaries. An examination of his career and his conception of engineering, of the evolution of engineering standards and codes, and of the process of formulating codes in particular instances explains how international standards can shape practice in an international context.

Let a trace be a computably enumerable set of natural numbers such that V[m]={n:〈n,m〉∈V}\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${V^{[m]} = \{n : \langle n, m\rangle \in V \}}$$\end{document} is finite for all m, where 〈.,.〉\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\langle^{.},^{.}\rangle}$$\end{document} denotes an appropriate pairing function. After looking at some basic properties of traces like that there is no uniform enumeration of all traces, we prove varied results on traceability and variants thereof, where (...) a function f:N→N\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${f : \mathbb{N} \rightarrow \mathbb{N}}$$\end{document} is traceable via a trace V if for all m,〈f(m),m〉∈V.\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${m, \langle f(m), m\rangle \in V.}$$\end{document} Then we turn to lattices Ltr(V)=({W:V⊆WandWatrace},⊆),\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\textit{\textbf{L}}_{tr}(V) = (\{W : V \subseteq W \, {\rm and} \, W \, {\rm a} \, {\rm trace}\}, \, \subseteq),$$\end{document}V a trace. Here, we study the close relationship to E=({A:A⊆Nc.e.},⊆)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathcal{E} = (\{A : A \subseteq \mathbb{N} \quad c.e.\}, \subseteq)}$$\end{document}, automorphisms, isomorphisms, and isomorphic embeddings. (shrink)

Manfred Eigen employs the terms language and communication to explain key recombination processes of DNA as well as to explain the self-organization of human language and communication: Life processes as well as language and communication processes are governed by the logic of a molecular syntax, which is the exact depiction of a principally formalizable reality.

Jahrhunderts. Der Sammelband bietet ausgewählte Beispiele ihrer Rezeption. Näher in Betracht kommen F.H. Jacobi, C. Daub, A. Schopenhauer, J. Müller, S. Kierkegaard, P. Tillich und M. Heidegger."--Publisher's website.

In Anknüpfung an eine Arbeit von 2006 zur Frequenzvereinbarung am Behandlungsbeginn greifen die Autorinnen das Thema des Settings und des Handlungsdialogs erneut auf, diesmal anhand eines Behandlungsverlaufs. Bei Patienten, die frühe Traumata erlebt haben, die nicht erzählbar sind, weil sie vor der Zeit liegen, in der das autobiographische Gedächtnis etabliert ist, spielt die Angstregulierung eine fundamentale Rolle. Hochfrequenz kann bei diesen Patienten Ängste auslösen, die als nicht steuerbar erlebt oder befürchtet werden. Ein niederfrequentes Setting ist hier oft – vor (...) allem am Beginn der Behandlung – das, worauf Analytiker und Patient sich verständigen können. Ein Frequenzwechsel wird möglich, wenn Fortschritte in der Symbolisierungsfähigkeit es erlauben, dass Ängste als solche wahrnehmbar und nicht mehr überwiegend agiert oder somatisiert werden. Dieser Entwicklungsprozess wird ausführlich an einer Behandlung dargestellt, die in wiederholten Intervisionen begleitet wurde. (shrink)

"Sept lettres, pas une de plus, échangées par la philosophe Simone Weil et le poète Joë Bousquet entre avril et mai 1942. Elles font suite à une rencontre que l'urgence du départ attendu par Simone Weil vouait à rester sans lendemain. A la veille de cette rencontre provoquée par Jean Ballard, directeur des Cahiers du Sud, ils ne se connaissaient pas personnellement, si ce n'est par quelques-uns de leurs écrits respectifs. Chacun attendant beaucoup de l'autre, leur "conversation nocturne" (...) fut dense et riche. Ils firent l'un sur l'autre une impression profonde. Intellectuellement, beaucoup les opposait : l'une avait fait le choix, remontant à Platon, du réel contre le rêve ; pour l'autre, au contraire, la quête du réel passait par le rêve. Ce fut pourtant le poète qui amena la philosophe à l'aveu des états mystiques qu'elle connaissait. Délivrée en quelque sorte de son secret, Simone Weil put alors laisser libre cours au flot tumultueux et magnifique de ses grands textes mystiques qui, tous, précédèrent son départ pour les Etats-Unis. Ainsi, sans cette rencontre et les lettres qui suivirent, notre connaissance de Simone Weil et de son oeuvre demeurerait incomplète. L'intensité de l'amitié qui se noua entre ces deux êtres laissa pourtant intacte la singularité de chacun. C'est ce que sut résumer Joë Bousquet en une phrase lapidaire : "Ses pensées étaient les miennes mais elle se reposait dans les pensées qui m'ôtaient le repos.""--Page 4 de la couverture. (shrink)

Universalism vs. Communitarianism focuses on the question, raised by recent work in normative philosophy, of whether ethical norms are best derived and justified on the basis of universal or communitarian standards. It is unique in representing both Continental and American points of view and both the older and a younger generation of scholars. The essays introduce the key issues involved in universalism vs. communitarianism and take up ethics in historical perspective, practical reason and ethical responsibility, justification, application and history, and (...) communitarian alternatives. Based on a special issue of the Journal Philosophy and Social Criticism, the book includes two additional essays by Chantal Mouffe and by Hubert and Stuart Dreyfus. David Rasmussen is Professor of Philosophy at Boston College and editor of Philosophy and Social Criticism. Contents: introduction, David, Rasmussen. Universalisms: Procedural, Contextualist, and Prudential, Alessandro Ferrara. Beyond Liberalism and Communitarianism: Toward a Critical Theory of Social Justice, Gerald Doppelt. The Liberal/Communitarian Controversy and Communicative Ethics, Kenneth Baynes. Discourse Ethics and Civil Society, Jean Cohen. Equality, Political Order and Ethics: Hobbes and the Systematics of Democratic Rationality, Rolf Zimmermann. Atomism and Ethical Life: On Hegel's Critique of the French Revolution, Axel Honneth. The Gadamer-Habermas Debate Revisited: The Question of Ethics, Michael Kelly. What Is and What Is Not Practical Reason? Agnes Heller. Adorno, Heidegger, and Postmodernity, Hauke Brunkhorst. Impartial Application of Moral and Legal Norms: A Contribution to Discourse Ethics, Klaus Günther. An Ethics, Politics, and History, Jürgen Habermas in an interview conducted by Jean-Marc Ferry. Rawls: Political Philosophy without Politics, Chantal Mouffe. What Is Morality: A Phenomenological Account of the Development of Ethical Expertise, Hubert L Dreyfus, Stuart E. Dreyfus. Universalism and Communitarianism: A Bibliography, Michael Zilles. (shrink)

O texto busca refletir criticamente sobre alguns fenômenos sociais contemporâneos, fortemente imbricados, notadamente as tendências contemporâneas de entrincheiramento e achatamento do eu; o reforço da iconomania e da compulsiva produção de avatares de si, em meio a bolhas narcísicas digitais, franqueadas pelas recentes tecnologias de informação e comunicação; e a virtual destruição da intimidade e da privacidade, diante da emergência de panópticos digitais e da vigilância algorítmica. Para tanto, toma-se como ponto de partida proposições apresentadas por Christopher Lasch em sua (...) obra _The Minimal Self: Psychic Survival in Troubled Times_, publicada originalmente em 1984, em particular a própria noção de mínimo eu, as quais são, então, entretecidas com argumentos de Christophe Dejours, Günther Anders, Theodor Adorno, Hebert Marcuse, Jonathan Crary, entre outros. Em acréscimo, busca-se salientar a ancoragem desses processos à hodierna dinâmica de acumulação de capital, a partir da crítica da economia política, perspectiva que atravessa todo o texto, bem como assinalar a atualidade do pensamento de Lasch. (shrink)

Like other works in the Philosophes series, this one has a tripartite presentation of life, philosophy, and excerpts; as Mme. Davy points out, Simone Weil did not prepare her own work for publication. About half of Weil's now published works are represented, with a selection from Attente de Dieu on the beauty of the world, and one from the Cahiers on the relation between God and man receiving the most attention. Unfortunately, the author's introduction, though lengthy, is quite (...) inadequate and often naïve, and the reader finds himself wishing she had directed her efforts to a more generous selection of primary material. Mme. Davy's treatment of Simone Weil's colorful life is cloudy, and her extraordinary subject remains a fairly anonymous elle. As for the exposition of Weil's philosophy, Mme. Davy wastes time on superficial rhetorical considerations like: "Was Simone Weil a philosopher? Did she have a metaphysic? Was she a religious thinker?" Only at moments, as for example in her discussion of some aspects of Weil's mystical and social thought, does Mme. Davy's text prove helpful.—C. M. R. (shrink)